Publications

Perthes Disease Related Publications by IPSG Members


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Kuroyanagi, G., Kamiya, N., Yamaguchi, R. & Kim, H. K. W. Interleukin-6 receptor blockade improves bone healing following ischemic osteonecrosis in adolescent mice. Osteoarthr Cartil Open 5, 100386 (2023). Download
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Buko, E. O. et al. Intravoxel incoherent motion (IVIM) detects femoral head ischemia in a piglet model of Legg-Calvé-Perthes disease. J Orthop Res (2023) http://doi.org/10.1002/jor.25733.
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Novais, E. N. et al. Treatment of Symptomatic Residual Deformity in Legg-Calvé-Perthes Disease: Mid-Term Outcomes and Predictors of Failure After Surgical Hip Dislocation with Femoral-Head Reshaping and Relative Neck Lengthening. J Bone Joint Surg Am 105, 1481–1488 (2023).
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Joseph, B., Shah, H. & Perry, D. C. Epidemiology, natural evolution, pathogenesis, clinical spectrum, and management of Legg-Calvé-Perthes. J Child Orthop 17, 385–403 (2023). Download
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Ma, C. et al. Local BMP2 hydrogel therapy for robust bone regeneration in a porcine model of Legg-Calvé-Perthes disease. NPJ Regen Med 8, 50 (2023). Download
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Melin, L., Rendek, Z. & Hailer, Y. D. Recommendations for physiotherapy and physical activity for children with Legg-Calvé-Perthes disease: a survey of pediatric orthopedic surgeons and physiotherapists in Sweden. Acta Orthop 94, 432–437 (2023). Download
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Kang, M. S., Kak, A., Prasadh, J. G. & Kim, H. K.-W. Reliability of the Modified Method for Sphericity Deviation Score Using Only the Involved Hip Radiographs in the Patients With Legg-Calve-Perthes Disease. J Pediatr Orthop 43, e554–e560 (2023).
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Prasadh, J. G., Jo, C.-H. & Kim, H. K. W. Patient Adherence to Wide Abduction Brace Treatment for Legg-Calvé-Perthes Disease. J Pediatr Orthop 43, 440–446 (2023).
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LaGreca, J., Nickel, A., Finch, M., Martin, B. D. & Laine, J. C. Declining Rates of Legg-Calvé-Perthes Surgery in the United States: National Trends Using the Kids’ Inpatient Database and Pediatric Health Information System. J Pediatr Orthop 43, 343–349 (2023).
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Shaw, K. A. & Herring, J. A. Skeletal Maturity in Legg-Calve-Perthes Disease: Significant Discrepancy Present Between the Hand and the Hip. J Pediatr Orthop 43, 294–298 (2023).
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Shah, H., Singh, K. A. & Joseph, B. Does Prolonged Weight Relief Increase the Chances of a Favourable Outcome After Containment for Perthes Disease? J Pediatr Orthop 43, e144–e150 (2023).
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Kim, H. et al. Local Administration of Bone Morphogenetic Protein-2 Using a Hydrogel Carrier for Robust Bone Regeneration in a Large Animal Model of Legg-Calvé-Perthes disease. Res Sq rs.3.rs-2465423 (2023) http://doi.org/10.21203/rs.3.rs-2465423/v1. Download
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Novotny, S. A. et al. Do Weightbearing Restrictions Cause Excess Weight Gain in Children With LEGG-Calvé-Perthes Disease? J Pediatr Orthop 43, 31–36 (2023).
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Kim, H. K. W., Almakias, R., Millis, M. B., Vakulenko-Lagun, B. & International Perthes Study Group. How are adults who had Perthes’ disease functioning? : results of over 900 participants from an international web-based survey. Bone Joint J 104-B, 1304–1312 (2022).
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Shah, H., Singh, K. A. & Joseph, B. The ‘Discoid Epiphysis’-An Uncommon Presentation of Legg-Calvé-Perthes Disease. J Pediatr Orthop 42, e570–e576 (2022).
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Peck, J. B. et al. Prolonged non-weightbearing treatment decreases femoral head deformity compared to symptomatic treatment in the initial stage of Legg-Calvé-Perthes disease. J Pediatr Orthop B 31, 209–215 (2022).
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McGuire, M. F. et al. What is the adult experience of Perthes’ disease? : initial findings from an international web-based survey. Bone Jt Open 3, 404–414 (2022).
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Morris, W. Z., Valencia, A. A., McGuire, M. F. & Kim, H. K. W. The Role of the Artery of Ligamentum Teres in Revascularization in Legg-Calve-Perthes Disease. J Pediatr Orthop 42, 175–178 (2022).
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Singh, K. A., Guddattu, V. & Shah, H. Radiologic Outcomes of Bilateral and Unilateral Perthes Disease: A Comparative Cohort Study. J Pediatr Orthop 42, e168–e173 (2022).
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Johnson, C. P. et al. T1ρ and T2 mapping detect acute ischemic injury in a piglet model of Legg-Calvé-Perthes disease. J Orthop Res 40, 484–494 (2022).
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Moreno Grangeiro, P. et al. Feasibility of Magnetic Resonance Angiography in Patients With Legg-Calvé-Perthes Disease. J Pediatr Orthop 41, e774–e779 (2021).
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Singh, K. A., Harne, N. & Shah, H. Does early and aggressive management of significant extrusion of the femoral head affect the outcome of Perthes’ disease with the age of onset younger than 7 years? Musculoskelet Surg (2021) http://doi.org/10.1007/s12306-021-00709-8. Download
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Selberg, C. M. et al. Hip Morphology in Early-stage LCPD: Is There an Argument for Anatomic-specific Containment? J Pediatr Orthop (2021) http://doi.org/10.1097/BPO.0000000000001791.
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Tis, J. E. et al. Reproducibility of Radiographic Measurements Made in the Active Stages of Legg-Calvé-Perthes Disease: Evaluation of a Prognostic Indicator and an Interim Outcome Measure. J Pediatr Orthop 41, 93–98 (2021).
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Kamiya, N. & Kim, H. K. Elevation of Proinflammatory Cytokine HMGB1 in the Synovial Fluid of Patients With Legg-Calvé-Perthes Disease and Correlation With IL-6. JBMR Plus 5, e10429 (2021).
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Abril, J. C., Montero, M. & Ismael, M. F. Legg-Calvé-Perthes’ disease. Congruent aspherity caused by physeal injury. Rev Esp Cir Ortop Traumatol (2021) http://doi.org/10.1016/j.recot.2020.06.011.
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Mörlin, G. B. & Hailer, Y. D. High blood pressure and overweight in children with Legg-Calvé-Perthes disease: a nationwide population-based cohort study. BMC Musculoskelet Disord 22, 32 (2021).
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Do, D.-H., McGuire, M. F., Jo, C.-H. & Kim, H. K. W. Weightbearing and Activity Restriction Treatments and Quality of Life in Patients with Perthes Disease. Clin Orthop Relat Res Publish Ahead of Print, (2020).
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Laine, J. C. et al. Reliability of the modified lateral pillar classification for Legg Calvé Perthes disease performed by a large group of international paediatric orthopaedic surgeons. J Child Orthop 14, 529–536 (2020). Download
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Laine, J. C. et al. Demographics and Clinical Presentation of Early-Stage Legg-Calvé-Perthes Disease: A Prospective, Multicenter, International Study. J Am Acad Orthop Surg (2020) http://doi.org/10.5435/JAAOS-D-19-00379.
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Abril, J. C., Montero, M., Egea-Gámez, R. M. & Ismael, M. F. Ellipsoidal process of the femoral head in Legg-Calvé-Perthes disease. Part I. J Pediatr Orthop B (2020) http://doi.org/10.1097/BPB.0000000000000748.
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Matsumoto, H. et al. Validation of Pediatric Self-Report Patient-Reported Outcomes Measurement Information System (PROMIS) Measures in Different Stages of Legg-Calvé-Perthes Disease. J Pediatr Orthop 40, 235–240 (2020).
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Leo, D. G. et al. The outcomes of Perthes’ disease. Bone Joint J 102-B, 611–617 (2020).
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Selberg, C. M., Chidsey, B., Skelton, A. & Mayer, S. Pelvic Osteotomies in the Child and Young Adult Hip: Indications and Surgical Technique. J Am Acad Orthop Surg 28, e230–e237 (2020).
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Alves do Monte, F. et al. Development of a novel minimally invasive technique to washout necrotic bone marrow content from epiphyseal bone: A preliminary cadaveric bone study. Orthop Traumatol Surg Res (2020) http://doi.org/10.1016/j.otsr.2020.01.006.
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Sankar, W. N. et al. Does Early Proximal Femoral Varus Osteotomy Shorten the Duration of Fragmentation in Perthes Disease? Lessons From a Prospective Multicenter Cohort. J Pediatr Orthop (2019) http://doi.org/10.1097/BPO.0000000000001451.
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Matsumoto, H. et al. Validation of Pediatric Self-Report Patient-Reported Outcomes Measurement Information System (PROMIS) Measures in Different Stages of Legg-Calvé-Perthes Disease. J Pediatr Orthop (2019) http://doi.org/10.1097/BPO.0000000000001423.
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Johnson, C. P. et al. Quantitative susceptibility mapping detects neovascularization of the epiphyseal cartilage after ischemic injury in a piglet model of legg-calvé-perthes disease. J Magn Reson Imaging 50, 106–113 (2019).
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Hedelin, H. et al. Innominate Salter osteotomy using resorbable screws: a retrospective case series and presentation of a new concept for fixation. J Child Orthop 13, 310–317 (2019). Download
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Shen, Z.-H. et al. Morphometric Characteristics of Sacral-2 Alar Iliac Screw Fixation in Pediatric Population. Spine 44, E571 (2019).
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Morris, W. Z., Liu, R. W., Chen, E. & Kim, H. K. Analysis of Trabecular Microstructure and Vascular Distribution of Capital Femoral Epiphysis Relevant to Legg-Calve-Perthes Disease. J. Orthop. Res. (2019) http://doi.org/10.1002/jor.24311.
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Hedelin, H., Swinkels, C. S., Laine, T., Mack, K. & Lagerstrand, K. Using a 3D Printed Model as a Preoperative Tool for Pelvic Triple Osteotomy in Children: Proof of Concept and Evaluation of Geometric Accuracy. J Am Acad Orthop Surg Glob Res Rev 3, e074 (2019). Download Download
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Shore, B. J., Miller, P. E., Zaltz, I., Schoenecker, P. L. & Sankar, W. N. Determining Hinge Abduction in Legg-Calvé-Perthes Disease: Can We Reliably Make the Diagnosis? J Pediatr Orthop 39, e95–e101 (2019).
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Jandl, N. M., Schmidt, T., Schulz, M., Rüther, W. & Stuecker, M. H. F. MRI and sonography in Legg-Calvé-Perthes disease: clinical relevance of containment and influence on treatment. J Child Orthop 12, 472–479 (2018). Download
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Laine, J. C., Martin, B. D., Novotny, S. A. & Kelly, D. M. Role of Advanced Imaging in the Diagnosis and Management of Active Legg-Calvé-Perthes Disease. J Am Acad Orthop Surg 26, 526–536 (2018).
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Aruwajoye, O. O., Monte, F., Kim, A. & Kim, H. K. W. A Comparison of Transphyseal Neck-Head Tunneling and Multiple Epiphyseal Drilling on Femoral Head Healing Following Ischemic Osteonecrosis: An Experimental Investigation in Immature Pigs. J Pediatr Orthop (2018) http://doi.org/10.1097/BPO.0000000000001219.
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Schmitz, M. R., Blumberg, T. J., Nelson, S. E., Sees, J. P. & Sankar, W. N. What’s New in Pediatric Hip? J Pediatr Orthop 38, e300–e304 (2018).
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Kessler, J. I. & Cannamela, P. C. What are the Demographics and Epidemiology of Legg-Calvé-Perthes Disease in a Large Southern California Integrated Health System? Clin. Orthop. Relat. Res. 476, 2344–2350 (2018).
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Johnson, C. P. et al. Quantitative MRI Helps to Detect Hip Ischemia: Preclinical Model of Legg-Calvé-Perthes Disease. Radiology 289, 386–395 (2018).
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Kuroyanagi, G. et al. Interleukin-6 deletion stimulates revascularization and new bone formation following ischemic osteonecrosis in a murine model. Bone 116, 221–231 (2018).